In the past decade, the chemistry of Amberlyst-15 has experienced a rapid development. This
growing interest in Amberlyst-15 is mainly due to its mild and highly selective properties,
combined with its environmentally benign character and commercial availability. Amberlyst-15 is now routinely used in organic synthesis as other heterogeneous reusable acid catalysts1a-d for various selective transformations of simple and complex molecules. The purpose of the present review is to summarize the utility of Amberlyst-151e-i with emphasis on recent synthetic applications; literature coverage is through the end of 2011.