Long-acting calcium-channel blockers also appear to be safe in pregnancy, although experience is more limited than with labetalol.21 Diuretics were long considered contraindicated in pregnancy because of concern about volume depletion. However, a review of nine randomized trials showed no significant difference in pregnancy outcomes among women with hypertension who took diuretics and those who took no antihypertensive medication.22 Accordingly, some guidelines support the continuation of diuretic therapy during pregnancy in women with chronic hypertension who were previously treated with these agents.17,18