The result of the present study validated traditional use of Ocimum sanctum for treating
cardiovascular disease for the first time by testing antiinflammatory activity of Ocimum sanctum in acute
inflammatory model, LPS induced THP-1 cells. The plant extracts showed significant antiinflammatory
activity, however, further to be evaluated using chronic inflammatory animal models like diabetic or
apolipoprotein E-deficient mice to make it evidence based medicine. The phenolic compound eugenol
(60 mg/mL) showed significant antiinflammatory activity. However the amount of eugenol present in
1 mg of OSAE and OSWE (12 ng/mg and 19 ng/mg dwt respectively) used for cell based assays was very
low. It suggests that several other metabolites along with eugenol are responsible for the efficacy of the
extracts