The main objectives of this study were to test, in a controlled study, the efficacy of a VR-MIP (“The Relaxation House”) to induce relaxation and sense of presence, and to analyze whether the stimulation of the senses of touch and smell improves the efficacy of this VR-MIP for inducing relaxation and sense of presence. Data provide evidence supporting the first hypothesis, that is, the efficacy of this VR-MIP for inducing relaxation. After mood-induction, the relaxation level increased, and the arousal level decreased significantly; likewise, results show significant changes in other emotions (joy, affective valence, anxiety, and sadness). It is important to note two important aspects: (1) this study was carried out with a non-clinical sample, which means that the participants did not have any significant psychological problems related to anxiety and/or depression; (2) the relaxation level of participants before the mood-induction was high (see Table 1); this is an important aspect to consider because, although the initial relaxation average was high, the VR was able to increase it even more.