Sixty patients (age; 69.66
7.53, weight; 81.56
14.43 kg, 10 male, 50 female) followed up four
or more years were randomly divided into two groups. An 8-week exercise program was designed for
bilateral TKA patients. While the patients in one group were assigned to weighted exercise group, the
patients in the other group were assigned to non-weighted exercise group. The primary outcome was the
isometric muscle strength of quadriceps femoris (QF) and hamstring muscles assessed by Hand-Held
Dynamometer. The secondary outcomes were the pain level, 30 s sit-to-stand test, 10 m walk test, range
of motion, and the knee function score of the Hospital for Special Surgery. The assessments were
performed before and after the treatment.