5 HT caused shivering and vasoconstriction and a concomitant rise in core temperature while, nor epinephrine and epinephrine lowered the normal resting temperature in cat and attenuated the 5 HT induced hyperthermia.The balance between the modulatory 5 HT and nor epinephrine inputs may be responsible for short and long term thermoregulatory adaptive modifications of the shivering threshold.32 Dopamine has also been found to induce hypothermia to a lesser extent in unanaesthetised monkey when injected into hypothalamus.