There is some controversy about complications of surfactant replacement therapy in different
studies. Meberg et al reported that in infants who had received surfactant for RDS the incidence of
air leak syndromes during mechanical ventilation was low[18]. Study of Geary et al in 2008 revealed
that successful early management of extremely preterm infants with surfactant treatment followed by CPAP is associated with reduction in the incidence and severity of bronchopulmonary dysplasia[19].