Several studies have demonstrated that elevated levels of
PCT indicate bacterial infection accompanied by a systemic
inflammatory reaction [12]. Nevertheless, PCT elevation
has been documented in infection-independent
systemic inflammatory reactions. In recent studies, PCT
levels were found to correlate with the extent of coronary
artery disease and adverse outcome [24]. In a retrospective
study, CS patients showed high PCT concentrations, especially
in the presence of MOF and in the absence of signs
of infection [25]. In a further investigation, PCT values
were significantly higher in CS patients compared with
patients with uncomplicated AMI [26]. The prognostic
relevance of PCT in CS was not evaluated. In our study,
both survivors and nonsurvivors reached maximum levels of PCT at T1. Significant differences between the two
groups were seen at T1 and T2 and were strongly associated
with outcome. ROC analysis showed the highest
accuracy of predicting 30-day mortality for PCT at T1 and
T2 with a sensitivity and specificity between 80% and 90%.
Notably, when comparing the area under the curve of NtproBNP,
IL-6, and PCT, at all points in time, PCT at T1
showed the highest value.
Several studies have demonstrated that elevated levels of
PCT indicate bacterial infection accompanied by a systemic
inflammatory reaction [12]. Nevertheless, PCT elevation
has been documented in infection-independent
systemic inflammatory reactions. In recent studies, PCT
levels were found to correlate with the extent of coronary
artery disease and adverse outcome [24]. In a retrospective
study, CS patients showed high PCT concentrations, especially
in the presence of MOF and in the absence of signs
of infection [25]. In a further investigation, PCT values
were significantly higher in CS patients compared with
patients with uncomplicated AMI [26]. The prognostic
relevance of PCT in CS was not evaluated. In our study,
both survivors and nonsurvivors reached maximum levels of PCT at T1. Significant differences between the two
groups were seen at T1 and T2 and were strongly associated
with outcome. ROC analysis showed the highest
accuracy of predicting 30-day mortality for PCT at T1 and
T2 with a sensitivity and specificity between 80% and 90%.
Notably, when comparing the area under the curve of NtproBNP,
IL-6, and PCT, at all points in time, PCT at T1
showed the highest value.
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