Several studies reported in-hospital mortality rate of 11–24% [38] and 22–35.6% after 1 and 2 yrs, respectively [58, 59]. None of these studies have specifically examined the prognostic influence of acute exacerbation by itself. SOLER-CATALUNA et al. [61] were the first to report that severe exacerbations of COPD have an independent negative prognostic impact, with mortality increasing with the frequency of severe exacerbations and those requiring hospitalisation. Patients with frequent exacerbations had the highest mortality rate (p,0.001) with a risk of death 4.3 times greater (95% CI 2.62–7.02) than for patients requiring no hospital management. Thus, exacerbation itself may be a significant factor associated with increased mortality in COPD, but the severity of the underlying disease may influence patient’s outcome.
Several studies reported in-hospital mortality rate of 11–24% [38] and 22–35.6% after 1 and 2 yrs, respectively [58, 59]. None of these studies have specifically examined the prognostic influence of acute exacerbation by itself. SOLER-CATALUNA et al. [61] were the first to report that severe exacerbations of COPD have an independent negative prognostic impact, with mortality increasing with the frequency of severe exacerbations and those requiring hospitalisation. Patients with frequent exacerbations had the highest mortality rate (p,0.001) with a risk of death 4.3 times greater (95% CI 2.62–7.02) than for patients requiring no hospital management. Thus, exacerbation itself may be a significant factor associated with increased mortality in COPD, but the severity of the underlying disease may influence patient’s outcome.
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