Facebook's Mark Zuckerberg and his wife Priscilla Chan say they will give away 99% of their shares in the company to good causes as they announce the birth of their daughter Max.
Mr Zuckerberg made the announcement in a letter to Max on his Facebook page.
He said they are donating their fortune to the Chan Zuckerberg Initiative because they want to make the world a better place for Max to grow up in.
Mr Zuckerberg said the donation currently amounts to $45bn (£30bn).
Max was born last week, but the couple only made the news of her birth public on Tuesday.
In his letter Mr Zuckerberg said the aim of the Chan Zuckerberg Initiative is "to advance human potential and promote equality for all children in the next generation".
Its initial areas of focus will be personalised learning, curing disease, connecting people and building strong communities.
"Your mother and I don't yet have the words to describe the hope you give us for the future," Mr Zuckerberg said at the start of his letter to Max.
"You've already given us a reason to reflect on the world we hope you live in," it added.
Dave Lee, BBC North America Technology Reporter, San Francisco
Billionaire investor Warren Buffet congratulated Zuckerberg and Chan, proclaiming that when it comes to giving away your fortune, "30 is the new 70".
No longer should billionaires wait to die before handing over money to a different generation, Buffet said, in a gushing approval of Silicon Valley's newest and most influential power couple.
Everything Mark Zuckerberg does is eyed with intense scrutiny, not least due to the nature of Facebook's business of making money from personal data.
But while the 31-year-old's previous charitable efforts have been criticised for being too focused on building Facebook's user base, this latest pledge appears to leave the Facebook business to one side.
It's a continuation of what we've seen developing over the past six months, where Zuckerberg appears at ease hosting heads of state as he does in the company of his own development team.