Current research results have allowed us to elucidate a part of the mechanisms involved in the pathogenesis of one of the most common skin disorders, acne and critically revisit conventional concepts of its pathogenesis. In addition, it has helped us to determine new targets for future drug development. The sebaceous gland cell is a key player in the initiation of the disease and sebocyte culture models have become so far very useful tools to provide new chances for further research.