5. What are the major management challenges to building and using information systems? There are five key management challenges in building and using information systems: (1) designing systems that are competitive and efficient; (2) understanding the system requirements of a global business environment; (3) creating an information architecture that supports the organization's goals; (4) determining the business value of information systems; and (5) designing systems that people can control, understand, and use in a socially and ethically responsible manner.