patients with severe sepsis should receive daily pharmacoprophylaxis against venous thromboembolism (VTE; grade 1B), preferably using daily sub- cutaneous low-molecular weight heparin (LMwh) (grade 1B) rather than unfractionated heparin 2 or 3 times daily (grade 2C). Importantly, if creatinine clearance is less than 30 mL/min, the use of dal- teparin (grade 1A) or another form of LMwh that has a low degree of renal metabolism (grade 2C) or unfractionated heparin (grade 1A) is recommended.