The objectives of this study were to
evaluate a) the effects of 17β-estradiol on cell survival and heat shock protein27
(Hsp27) expression in SHSY5Y cells and injured rats, b) The effects of 17β-estradiol
and reproductive aging on motor function, neuronal death, and white matter sparing
after SCI. Heat stress induced Hsp27 upregulation and showed strong cytoprotective
effects on H2O2 induced cell death in SHSY5Y cells and this benefit was abolished by
Hsp27 antibody treatment.