Methods: Electronic databases (MEDLINE, EMBASE, Cochrane Trial Register) were searched up to August 2012 with
no restriction to language or calendar date. A random effect meta-analysis was performed using the Software
package by the Cochrane Collaboration Review Manager 5.1. Sensitivity analysis was performed for RCTs with a
Jadad Score ≥3, and excluding type 2 diabetic subjects (T2D).