The Federal Reserve Bank of St. Louis is one of 12 regional Reserve Banks that, along with the Board of Governors in Washington, DC, make up the United States' central bank . Missouri is the only state to have two Federal Reserve Banks. ( Kansas City also has a bank .) Located in downtown St. Louis , the St. Louis Fed is the headquarters of the Eighth Federal Reserve District, which includes the state of Arkansas and portions of Illinois , Indiana , Kentucky , Mississippi , the eastern half of Missouri and West Tennessee . It has branches in Little Rock , Louisville and Memphis . Its building