Results Thirteen studies were included, eight of which used resin-based
material and were selected for meta-analysis. The pooled estimate of effect
for a single application of resin-based sealant on first permanent molars
showed the RR of developing caries in sealed teeth relative to controls was
0.67 (95% confidence interval, 0.55–0.83), a reduction in RR of 33%. For
repeated applications, the reduction in RR varied from 69 to 93%.