Numbers of AV lesions is calculated at the beginning and at the end of the study and classified as inflamed (papules, pustules) and non-inflamed lesion (comedos). Photography in the face, upper chest and back were obtained by permission from the subjects. Standard therapy As an ethical reason, topical cream containing retinoic acid 0.025% have been given to all subjects (in control and treatment group) to be applied on AV lesions in the face only, during night time