As showed by the results of oxidation induction time and accelerated thermal aging tests, the GM-ME-TDI and GM-ME-IPDI exhibit excellent antioxidative ability for NR vulcanizates. On one hand, the urethane group in GM-ME-TDI and GM-ME-IPDI may play a role in inhibiting the degradation of NR vulcanizates, and its function is similar with aromatic amine antioxidant. On the other hand, the higher molecular weight leads to the decrease of the physical loss of antioxidant.