More importantly, these find could imply that knee OA patients with knee instability may not benefit optimally from standard exercises targeting muscle strength. An exercise program that additionally targets other biomechanical factors involved in the knee joint stabilization process could be more beneficial for this subgroup. Moreover, knee joint stabilization training may need to be specifically provided in the first, low-intense phase of the intervention, prior to higher-intensity strength training, as patients suffering from knee instability may not be able to perform strengthening exercises safely (i.e., without risking joint-specific adverse events) Currently, such an intervention has not been evaluated.