The present study suggests that ammoxetine produces more
potent analgesic effects than duloxetine in animal models of
inflammatory and continuous pain. Ammoxetine also had an
analgesic effect on neuropathic pain induced by SNI or CCI
and on pain associated with fibromyalgia induced by reserpine.
The pain-relieving mechanisms of ammoxetine could be
attributed to an increase in the transmission of 5-HT and NE
in the descending inhibitory pathways. Given the impressive
analgesic effects of ammoxetine, we consider the potential
effect and strategies directed to the treatment of neuropathic
pain and fibromyalgia.