Polyunsaturated fatty acid, the component of membrane cell by oxidative stress, will form malondialdehyde ( MDA) which has been recognized as an important lipid peroxidation indicator. This can be used as a marker for diagnosis and follow up the progress of AV. The level of MDA in AV patient has been shown higher than healthy person. Endogenous and exogenous antioxidant may play a role in scavenging free radicals influencing the severity of AV. Extensive laboratory research has suggested a strong link between the mechanisms by which oxidative stress leads to chronic inflammation, which in turn may mediate a wide array of chronic diseases including acne vulgaris.