Anthocyanins from black raspberries, blackberries, and strawberries protect against a number of hepatotoxic agents including nitrosamines (Reen et al., 2006). However, the mechanism by which AF elicits hepatoprotective and antioxidant effects in association with Nrf2 is unclear. Here, we report that AF attenuates DMN-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and attenuating the inflammatory mediators COX-2 and iNOS through the inhibition of NF-κB.