Oxidative stress is caused by an imbalance between the production
of reactive oxygen and a biological system’s ability to
readily detoxify the reactive intermediates or easily repair the
resulting damage [1,2]. All forms of life maintain a reducing environment
within their cells. This reducing environment is preserved
by enzymes that maintain the reduced state through a constant
input of metabolic energy. Disturbances in this normal redox state
can cause toxic effects through the production of peroxides and free
radicals that damage all components of the cell, including proteins,
lipids and DNA[3,4].Inhumans, oxidative stress is involvedinmany
diseases, such as diabetes mellitus, atherosclerosis, Parkinson’s disease,myocardial
infarction,Alzheimer’s disease and chronic fatigue
syndrome.
Diabetes mellitus is probably the fastest growing metabolic disease
in the world. Because of its heterogenic nature, diabetes makes
more challenging task and it needs more appropriate therapies [5].