For context: I'm 17 and have had moderate acne since I was 13. I tried everything OTC and nothing really worked. Last year, I went to a dermatologist and tried several different combinations (Epiduo + Doxycycline, Acanya + Doxycycline, etc) and finally, Acanya and Tretin-X (0.0375% tretinoin). That combination worked and I was the most clear I'd ever been since I started getting acne. My dermatologist then suggested I move to a stronger tretinoin (Retin-A Micro in 0.08% formulation) and that worked just as well, but also helped with my oiliness. I had a lapse in treatment (Tretin-X was discontinued, I couldn't find Retin-A Micro in that formulation, and I had no time to really follow my routine), but even some application overnight worked. I'm restarting with Aczone and Retin-A, but the lesson is: It takes time, but it will work.