Pruritusisnotthemostprevalentbutoneofthemostpuzzlingsymptomsinpalliativecarepatients.Itcancauseconsiderablediscomfort and has a major impact on patients’ quality of life. In the field of palliative care, pruritus is a symptom occurring in patients with disparate underlying diseases and based on different pathologic mechanisms but ending in the same phenomenon. The pathogenesis of pruritus is complex and not fully elucidated. Thus, it is still very difficult to treat pruritus effectively. Evidence-based treatment approaches are needed