and that intensive-dose statin therapy is associated with higher risk than is lower dose therapy (HR 1·12, 95% CI 1·04–1·22).4 In absolute terms, however, these risks are low compared with the absolute benefit of statin therapy in the setting of secondary prevention, from which most data are derived. We were unable to find any data directly addressing the cardiovascular benefits and diabetes risks in the setting of primary prevention, an issue that has caused much controversy in both the medical and lay press. Further, we were unable to find any data addressing whether the risks and benefits of statin therapy in primary prevention differ between people with and without risk factors for diabetes.
มีสามการวิเคราะห์meta-analyses ระหว่าง 2009 และ 2011 2–4 ยากลุ่ม statin มีเกี่ยวข้องกับการเพิ่มขึ้นเล็กน้อยในการเกิดความเสี่ยงของโรคเบาหวานชนิด2 (hazard ratio [HR] 1·09, 95% CI 1·02–1·17),3