The new genus cannot be placed in the known subfamilies following diagnosis provided by Raven (1985). However, with an amended diagnosis by Drolshagen and Bäckstam (2009) the new genus may be placed in the subfamily Diplurinae in bearing the synapomorphy of a single row of teeth on chelicerae. Within Diplurinae the Orientothele gen. nov. differs from Metriura in bearing a single row of teeth on superior tarsal claws (vs. 2 in Metriura), from Diplura, Trechona, and Harmonicon in lacking prolateral maxillary lyra (vs. absent in Diplura, Trechona, and Harmonicon).