We conceive of the proteins associated with a particle as possessing. We conceive of the proteins associated with a particle as possessing dissociate quickly to be replaced by proteins of lower concentration,slower exchange, and higher affinity18. Thus the protein corona is the
biological identity of a nanoparticle, as it is what the cell ‘sees’ and
interacts with. The exchange processes may also be important when
particles redistribute from one compartment or organ to another, such
as upon uptake into cells from the bloodstream, or upon transport from
the cytosol to the nucleus.