[3–5]. The infection reproduced in these animals follows
closely the processes occurring in humans infected
with EBO, therefore, allowing to determine the immunity
parameters that may be crucial in the immunopathogenesis
of the disease.
EBO has been adapted to guinea pigs [6,7] and mice
[8], thus expanding the range of animal models sensitive
to EBO. In particular, it has been shown that the EBO
adapted to guinea pigs demonstrates increased virulence
for these animals along with a decreased virulence
for newborn mice [6,7]. However, the effect of such
EBO adaptation on the course of Ebola fever in monkeys
was not previously reported.
In this study we monitored the dynamics of immune
and pathophysiological parameters, including indices of
both specific and nonspecific immunity, in EBO-sensitive
monkeys Papio hamadryas infected with EBO
adapted to guinea pigs