The effect of extraction conditions on polyphenols contents and condensed tannins by
microwave-assisted extraction (MAE) was studied for the first time to our knowledge. Moroccan
barks of Acacia mollissima was used to extract phenolic compounds. The variables studied are
the following: power extraction, time extraction and solvent nature. Five powers extraction were
tested: 150 W, 250 W, 300 W, 450 W and 600 W. A significant effect of power extraction on the
extractable nature was proved by ANOVA and Student test. The yields were also affected by time
extraction. Different solvent (water, ethanol, methanol and ethyl acetate) were tested to evaluate the
best extraction solvent according to the extractable nature. Highest polyphenols contents were
obtained with methanol. The proportion of this solvent, time extraction and power extraction were
optimized using the response surface methodology (RSM). A face-centered composite design
(FCCD) was applied to evaluate the effects of these variables on the polyphenols and condensed
tannins contents. For each experiment, the extraction yield, the total polyphenolic contents and