Samples were run on a Thermo Electron LTQ orbiteap Discovery mass spectrometer-a linear ion trap (LTQ XLL) MS,
coupled to a high precision electrostatic ion trap (Orditrap) MS with a high energy collision cell, an Ion max electrospray ionizatioo (ESI) source, and athermo scientific ACCELA series HPLC system, with Thermo scientic Xcalibur 2.1.0.1140 LC-ms software.