In summary, our results provided an unprecedented view into a
new recombinant A. hydrophila vaccine (SWCNT-Aera) induced
protective immunity to juvenile grass carps against A. hydrophila by
the host tissue immune responses. In this study, we found that the
bath immunization of Aera could not lead to alterations of the
major microbiota in grass carp and may be associated with defined
A. hydrophila-specific immunological responses. The analysis
revealed considerable Aeromonas variability between Aera-GD and
Control-GD, yet no discernible perturbations of the other bacterial
assemblage related to vaccine administration were observed.
Moreover, Aera mediated immune responses in intestine, kidney
and spleen were evaluated by measurement of immune-relevant
genes, in which the results exhibited significantly protective immunity.
Therefore, SWCNT-Aera vaccine may represent potentially
efficient and specific roles in grass carp intestine to resist
A. hydrophila infection.