In the last few years,ultrasonic-assisted materials synthesis became popular tocontrol some of the physical properties during the reaction [39]. Poinern et al 2011, prepared nHA via a wet precipitation method under ultrasonic irradiation using ammonium hydroxide as the precipitator. The study in vestigated the in fluence of the thermal treatment to produce ultrafine nHA powders using conventional furnace compared to MW-based technique. The results demonstrated that both
thermal techniques (assisted with ultrasonic radiation) effectively produced ultrafine powders with similar crystalline structure, morphology and particle sizes [39]. Others suggested the sonochemistry-assisted MW process to synthesize carbonated HA (CHA) with high efficiency [101]. CHA Nano-powders that were synthesized through this process were evaluated against the conventional precipitation method. The outcomes showed that the ultrasonic-assisted MW process
significantly in creasedthe synthetic efficiency and obtained high yield of well-crystallized Nano-powders in a very short time. Moreover, the specific surface area, dispersibility and the crystallization process of the obtained product were improved with the increase of ultrasonic and MW power and reaction time