To conclude, the data presented in this study support our
primary hypothesis that WBM possesses antiglycemic and
antihypercholesterolemic effects. Moreover, it has a
positive influence on lipid metabolism and liver function.
Based on studies of other mushrooms, the glucose- and
cholesterol-lowering effects of WBM are likely the result of
a number of mechanisms involving dietary fiber and other
active components in the mushroom acting alone or in
combination. Nonetheless, the marked metabolic effects
seen in our animal models suggest a potential nutritional
role of dietary WBM in the increasing rates of cardiovascular
disease, obesity, and type 2 diabetes in humans.
Nutritional studies are needed to examine the potential
benefits of the compounds in mushrooms in carefully
controlled clinical trials.