A simple indirect atomic absorption spectrophotometric (AAS) method is described for the analysis
of nimodipine in tablet formulations. The method is based on the reduction of the antihypertensive drug
substances including an aromatic nitro group by boiling them with cadmium metal in 0.05 N HC??l
medium under CO2 atmosphere for 1 h under reflux. The amounts of the drugs were calculated by
determining the atomic absorbances of the released Cd+2. The calibration graphs were plotted between
the absorbance Cd+2concentrations in the range of 0.242 to 1.209 µg.cm−3 for nimodipine. As a reference
method, the spectrophotometric procedure was developed. The 2 methods developed were applied to
the assay of nimodipine in commercial tablet formulations, and a statistical comparison of the results
with those obtained from the reference method showed good agreement. The method has the advantage
of being simple, inexpensive, and easy to perform.