Another follow up study however, has shown further
supportive evidence. Infusion of plasma from patients
with mild acute scrub typhus, reduced viral loads in 7 out
of 10 patients with HIV-1 infection. The beneficial effect
was observed up to 8 weeks after a single transfusion.
However, the in vivo impact of donor plasma was not seen
in all HIV infected patients[25]. Several hypotheses have
been developed to explain these observations including
an inhibitory antibody mediated response, restriction of
syncytia forming/maintenance of non syncytia inducing
phenotypes of virus and specific activity against certain
strains of the HIVvirus[26]. However the actual mechanism
for this observation remains an enigma.