Rapid diagnostic tests may be used. They are based on the detection of the insulin-like growth factor-binding protein-1 (IGFBP-1) and placental α-microglobulin-1 (PAMG1) in cervicovaginal secretions. AmniSure(®) test (PAMG-1) can be done without speculum, and Actim™Prom test (IGFBP-1) during speculum examination. Both tests have high sensitivity and specificity of about 95% (Marcellin et al, 2011).