Mills et al. (2007) followed the above studies with an evaluation of effects onmen with
prior myocardial infarction. Twenty men with stable coronary artery disease underwent
the same exposure protocol used in the preceding studies. Myocardial ischemia was
evaluated by analysis of the ST segment of the electrocardiogramduring exposure; plasma
markers and responses to vasodilators were measured at 6 h after exposure, using the
previous methods. A greater exercise-induced ST segment depression after diesel exposure
than after sham exposure indicated a proischemic effect. The responses to the
vasodilators were not altered by exposure, in contrast to the above findings with healthy
men. The release of endothelial plasminogen activator was reduced by exposure.
Together, the results from this group indicated that exposure to a high concentration of
diesel emissions can cause acute cardiovascular changes, some of which may persist
for 24 h