Vestibular and auditory effects
Ginkgo biloba extract improved the sum of action potentials in the cochlea and
acoustic nerve in cases of acoustically produced sound trauma in guinea-pigs (1,
65). The mechanism reduced the metabolic damage to the cochlea. Oral or
parenteral administration of a standardized G. biloba extract to mice (2mg/kg)
improved the ultrastructure qualities of vestibular sensory epithelia when the
tissue was fixed by vascular perfusion (66). Improvement was due to the effects
of the drug on capillary permeability and general microcirculation (1, 66).
Positive effects on vestibular compensation were observed after administration
of G. biloba extract (50 mg/kg intraperitoneally) to rats and cats that had
undergone unilateral vestibular neurectomy (67, 68).