Previously, we demonstrated that type I interferon (IFN-/) or a combination of IFN-/ and type II IFN
(IFN-) delivered by a replication-defective human adenovirus 5 (Ad5) vector protected swine when challenged
1 day later with foot-and-mouth disease virus (FMDV). To gain a more comprehensive understanding of the
mechanism of protection induced by IFNs, we inoculated groups of six swine with Ad5-vectors containing these
genes, challenged 1 day later and euthanized 2 animals from each group prior to