is no statistically significant difference in the genotypic or allelic frequencies of endothelial nitric oxide synthase polymorphisms between African American sickle cell dis- ease and control groups. In addition, eNOS gene poly- morphisms (rs2070744 and rs1799983) were equally distributed, with no deviations from the HardyeWeinberg equilibrium. This lack of difference in eNOS gene poly- morphisms between African and American sickle cell dis- ease groups imply observations made in one population could potentially be applied to the other, with disease following a similar pattern on eNOS polymorphisms in both populations. Potential contribution of genomic heteroge- neity in the control group30 to our results would require further deconvolution, since significant admixture in this group could be a confounding factor to our observations and attributable conclusions. Following up with our previ- ous report on the impact of geographical origin on genetic outcome among African American population,19 further studies evaluating this polymorphism in representative groups, recruited from other parts of the United States vis- a`-vis regional- or disease-specific selection pressures is imperative.