The Great Fire started in Thomas Farrinor's bakery on Pudding Lane and raged until September 5, destroying 80 percent of the mostly wooden, walled inner city.
An estimated 70,000 of the 80,000 residents were rendered homeless by the disaster. By the time the fire was extinguished a total of 13,200 houses, 87 churches and Saint Paul's Cathedral had been destroyed.
Recreating the fire on Sunday was part of a wider series of events to mark the anniversary of the inferno, celebrating the city's ability to rebuild and thrive.
Nick Bodger, head of cultural and visitor development for the City of London, said the capital's resilience – witnessed again during the 1940s Blitz – helped it rebuild and survive.