For combination with irinotecan, the recommended starting dose is 800 mg/m2 when administered twice daily for 14 days
followed by a 7-day rest period combined with irinotecan 200 mg/m2 on day 1.
The inclusion of bevacizumab in a combination regimen has no effect on the starting dose of capecitabine.
Premedication to maintain adequate hydration and anti-emesis according to the cisplatin summary of product characteristics should be started prior to cisplatin administration for patients receiving the capecitabine plus cisplatin combination. Premedication with antiemetics according to the oxaliplatin summary of product characteristics is recommended for patients receiving the capecitabine plus oxaliplatin combination.