The lysosome is the principal organelle responsible for the degradation of cellular waste. It is a common constituent of all cell types of the nervous system and is particularly prominent in neurons, where it can be seen at various stages of development (Fig. 1-4). It ranges in size from 0.1 to 2 μm in diameter. The primary lysosome is elaborated from Golgi saccules as a small, vesicular structure (Fig. 1-6). Its function is to fuse with the membrane of waste-containing vacuoles, termed phagosomes, into which it releases hydrolytic enzymes (see Chap. 41). The sequestered material is then degraded within the vacuole, and the organelle becomes a secondary lysosome; it is usually electron-dense and large. The matrix of this organelle will give a positive reaction when tested histochemically for acid phosphatase. Residual bodies containing nondegradable material are considered to be tertiary lysosomes, and in the neuron some are represented by lipofuscin granules (Fig. 1-7). These granules contain brown pigment and lamellar stacks of membrane material and are more common in the aged brain [7].