The official JIBCON Twitter account says that Padalecki had to pull out of the convention due to illness, writing, "We're very sorry to inform all fans that Jared isn't feeling well and can't join us in Rome @jarpad get well soon." Bodyguard Clif Kosterman confirms on his Twitter that Padalecki is "not feeling well."
However, fans are worried that it might be more than a stomach bug. One fan writes on Twitter that "Supernatural" co-star Misha Collins told her at a photo op that Padalecki has been pushing himself too hard and the "Supernatural" family told him to take it easy. Zap2it cannot verify the veracity of her claims.
RELATED: 'Supernatural' delivers the perfect love letter to fans
The same fan also cites Padalecki's recent Twitter bio change -- it now reads "I'm trying to do the best that I can" -- and a recent Facebook post where Padalecki asks his fans to tell him "something good that has happened because of 'Supernatural' or 'Always Keep Fighting'" as reasons why there might be more going on with Padalecki. The actor has been outspoken about his own past struggles with depression.