No baptisms, funeral services, weddings, or other traditional church services were held in the Church on the Blood, as this was not in Alexander III's plans. However, weekly requiems (for Alexander II) and sermon readings attracted large numbers of worshippers.
After the Revolution, the church - despite becoming an official cathedral in 1923 - was looted. It was closed in 1932, and essentially turned into a garbage dump. Rumors abounded that the church would be torn down. Damage from World War II and the Siege of Leningrad can still be seen on the church's walls.
After World War II, the church was used as a warehouse for the Small Opera Theatre. The valuable shrine was almost completely destroyed. Four jasper columns with mosaic mountings in them, and a part of the balustrade were all that remained.