Interestingly, burnout domains related specifically to work — measured using CBI Work and CBI Client subscales—were less closely associated with depression. Amongst the depressed patients in our study, a significantly smaller proportion reported feeling exhausted from work or client-related work compared to experiencing a general sense of physical or psychological fatigue. One possible explanation for this difference could be the phrasing of the questions in the scales. The CBI Work and Client subscales contain questions such as “Do you feel burnt out because of your work?” and “Does it drain your energy to work with clients?”. Such questions imply causality and ask the subjects to attribute their sense of fatigue or exhaustion to their work (Yehetal.,2007). It may be difficult for patients clinically diagnosed with mood disorders that can cause symptoms of low energy to distinguish whether their fatigue was caused by their psychiatric conditions or their work. The CBI Work and Client scores could have been lower than the CBI Personal scores if the subjects attributed some portion of their exhaustion to their illnesses. Furthermore, in addition to lower correlation coefficients with the QIDS-SR total score, CBI Work scores were only significantly correlated with seven of the major symptoms of depression and CBI Client scores with only three. CBI Client scores did not appear to correlate with anhedonia and depressed moods, which are considered the hall- mark symptoms of depression. Several studies have already demonstrated the distinctness of burnout in the three domains based on differences in long-term progression and job character- is tics (Borritz etal.,2005;Yehetal.,2007). Results of our study suggested that such distinctness may include how they relate to depression. While burnout in the personal domain closely over- lapped depression, burnout specifically related to work(or at least attributed to work by the person)could be a more distinct phenomenon from depression. In particular, it is possible that some aspects of working with clients can lead to a type of physical or psychological fatigue that is not associated with a higher risk of affective disturbance.