This affinity corresponds to the evaluation of the objective function.
Select the n highest affinity antibodies.
The n selected antibodies will be cloned proportionally to their affinities, generating a repertory Cof clones: the higher affinity the higher number of clones and vice versa.
The clones from C are subject to hypermutation process inversely proportional to their antigenic affinity. The higher affinity, the smaller mutation, and vice versa.
Determine the affinity of the mutated clones C.
From this set C of clones and antibodies, select the j highest affinity clones to compose the new antibodies’ population.
Replace the d lowest affinity antibodies by new individuals generated at random.
End repeat