Aloe is known as the healing plant. A. vera has been used for traditional medical purposes in several cultures. 22In vitro extracts of A. vera stimulate the proliferation of several cell types. Many studies have shown that treatment with whole A. vera gel extracts resulted in faster healing of wounds. 23 and 24A. vera may have a direct effect on the wound healing process as a whole, which is manifested by increase in rate of contraction of wound area 25 and has confirmed the effect of A. vera on increasing wound contraction and collagen synthesis. This property is attributed to the mannose-6-phosphate known to be present in A. vera gel. 26 Polysaccharides from Aloe promote both the proliferation of fibroblasts and the production of hyaluronic acid and hydroxyproline in fibroblasts, which play important roles in extracellular matrix remodeling during wound healing. 27 Acemannan, significantly increases periodontal ligament cell proliferation, upregulation of growth/differentiation factor 5, type I collagen and alkaline phosphatase activity in primary human periodontal ligament cells. 27 In a clinical study, to check the efficacy of A. vera gel compared with 1% silver sulfadiazine cream as a burn dressing for the treatment of superficial and partial thickness burns, healing of burn wounds were remarkably early in A. vera treated patients than those patients treated with 1% silver sulfadiazine. 28 Polysaccharides isolated from A. vera induce matrix mellatopeptidase (MMP)-3 and metallopeptidase inhibitor-2 gene expression during the skin wound repair of rat, which directly helps to regulate the wound healing activity of A. vera gel. 29